Kybele is a global leader in health-system strengthening that is internationally recognized for improving the quality and safety of healthcare during childbirth in low- and middle-income countries. Kybele teams consist of medical experts in anesthesiology, obstetrics, and neonatology along with implementation scientists. We establish partnerships with health ministries and local leaders to develop innovative, cost-effective solutions to healthcare problems. Our rigorous approach has been chronicled in over 25 peer-reviewed publications. Since its formation in 2001, Kybele has successfully implemented multifaceted programs with sustained impact in 13 countries in Africa and eastern Europe with over $4 million of support from governments, institutions, and foundations.