Kybele has been actively working in Ghana since 2007. We target high-volume regional and teaching hospitals that receive many high-risk patients and are often understaffed, ill-equipped, and inadequately resourced to provide the advanced maternal and neonatal clinical care needed for these patients. Ghana has an alarming maternal mortality rate of 263 deaths per 100,000 live births and a neonatal mortality rate of 22 deaths per 1,000 live births. Kybele has partnered with Ghana Health Service and health facilities that receive the most complicated, at-risk patients to build the capacity of frontline staff to provide advanced-level maternal and newborn clinical care, to support ongoing quality improvement, to provide essential equipment and supplies, to bring operational protocols in line with global standards and best practices, and to strengthen referral within and between hospitals. In addition, we were instrumental in the establishment of the third anesthesia training program in Ghana that filled a significant surgical service gap. Kybele has collaborated on numerous publicly and privately funded multi-year projects with USAID Ghana, the JSI Focus Regional Health Project, URC Systems for Health, PATH, Canadian Food for the Hungry, East Meets West Foundation, Access Bank, and Ghana International Women's Club. Most recently Kybele was awarded multi-million dollar funding from the Children's Investment Fund Foundation (CIFF) to implement the Making Every Baby Count Initiative (MEBCI 1.0 and 2.0) and from Grand Challenges Canada for that testing and transition to national scale of our Obstetric Triage Implementation Package (OTIP). Our evidenced based approach has garnered global attention and our achievements have been well chronicled in numerous peer-reviewed medical journals.